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Factor XIa: another anticoagulant? Not Quite. Could be gold standard

Amit Roy
Jul 10, 2021
1 min read

While uncharted territory inhibiting poorly investigated factor XIa, novel mechanism of action and early data and epidemiological studies suggest it could become the gold standard in Stroke prevention.

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Focus Research

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JNJ: JNJ4804 Despite likely efficacy, maintenance Rx concerns over combo in UC

New Imaavy faces headwinds from Myasthenia incumbents but promising in other FcRn markets

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VERA: IgAN: Atacicept phase III ORIGIN3: likely positive but Fabhalta will be hard to hurdle

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NOVN: Consensus missing large Fabhalta upside

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ADC: AZN Dato overall survival misses underscores our long held concerns for ADC's in 1L Lung

ADC: AZN Dato overall survival misses underscores our long held concerns for ADC's in 1L Lung

Recent Reseacrh

CNTA/4502/ALKS: Differentiation challenges for CNTA ORX750 orexin agonist vs Takeda in NT1&2, despite clean phase 1

RARE/MREO: ORBIT UX143 P2 improvements NOT solely due to natural progress seen with age

New Imaavy faces headwinds from Myasthenia incumbents but promising in other FcRn markets

New Imaavy faces headwinds from Myasthenia incumbents but promising in other FcRn markets

JNJ: JNJ4804 Despite likely efficacy, maintenance Rx concerns over combo in UC

New Imaavy faces headwinds from Myasthenia incumbents but promising in other FcRn markets

New Imaavy faces headwinds from Myasthenia incumbents but promising in other FcRn markets

JNJ: New Imaavy faces headwinds from Myasthenia incumbents but promising in other FcRn markets

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JNJ/PTGX: JNJ2113: Icotrokinra ANTHEM-Ulercative Colitis efficacy similar to oral competitors

JNJ/PTGX: JNJ2113: Concerns over upcoming (Q1) oral IL23 ANTHEM trial in Ulcerative Colitis

NOVN: Ianalumab’s unique Sjögren’s data, likely first

NOVN: Ianalumab’s unique Sjögren’s data, likely first

NOVN: Ianalumab’s unique Sjögren’s data, likely first

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NOVN: Consensus missing large Fabhalta upside

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NOVN/AMGN: Cholesterol-busting Lipoprotein (a) drugs likely to lead to new multibillion cardiovascular breakthrough

NOVN/AMGN: Cholesterol-busting Lipoprotein (a) drugs likely to lead to new multibillion cardiovascular breakthrough

NOVN/AMGN: Cholesterol-busting Lipoprotein (a) drugs likely to lead to new multibillion cardiovascular breakthrough

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