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Recent Research


Anti PD-L1s continue lacklustre rivalry with anti PD-1s
AstraZeneca received accelerated FDA approval for its anti PD-L1 durvalumab (Imfinzi) in 2nd line bladder cancer last week, making this...
May 8, 2017


High Hurdle for IDOs
IDOs from Incyte are back in focus with high response rates and better safety than the existing IO combos. But will they win out...
Apr 15, 2017


ROG.VX: FDA Label-Ocrevus ineffective in women with breast cancer risk
Despite ROG last week’s Ocrevus FDA approval for PPMS & RRMS, its lack of benefit in women with PPMS and increased cancer risk and little di
Apr 3, 2017


ROG:VX: APHINITY headline positive but await full data
Awaiting full data: Roche announced that APHINITY met its primary endpoint , but as expected details are to be published at an upcoming...
Mar 2, 2017


ROG.VX: APHINITY too close for comfort
We present the third update of our APHINITY analysis, originally published two years ago and find the risks of early stage Perjeta...
Feb 6, 2017


BMY.US: No Accelerated pathway does not imply registrational failure
Bristol's announcement that it is not pursuing an accelerated FDA approval pathway for Yervoy and Opdivo in first line lung cancer was...
Jan 20, 2017


AZN.LN: MYSTICal Endpoints unravelled
Endpoints claified: There have recently been some uncertainties surrounding the exact endpoint and timings of the upcoming MYSTIC IO/IO...
Jan 17, 2017


AZN.LN: Mystical Endpoints
What's the endpoint?: There have recently been some uncertainties surrounding the exact endpoint and timings of the upcoming MYSTIC combo...
Dec 3, 2016


AZN.LN: Head and neck hold may explain BMYs hesitance with combo
Head and neck specific? The FDA placed a partial clinical trial hold on recruiting new patients to AstraZeneca’s anti PD-L1 (durvalumab)...
Oct 27, 2016


PD1 Combos at ESMO good for AZN and BMY not for MRK and ROG
Chemo combos continue to look equivocal, while IO combos remain durable as MYSTIC’s shadow clears New ESMO lung cancer data bodes well...
Oct 17, 2016
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